MAGNITUDE CHANGES IN TRANSIENT EVOKED OTOACOUSTIC EMISSIONS AND HIGH-LEVEL 2F(1)-F(2) DISTORTION PRODUCTS IN MAN DURING QUININE ADMINISTRATION

被引:10
作者
BERNINGER, E [1 ]
KARLSSON, KK [1 ]
HELLGREN, U [1 ]
ESKILSSON, G [1 ]
机构
[1] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT CLIN PHARMACOL & INFECT DIS,HUDDINGE,SWEDEN
来源
SCANDINAVIAN AUDIOLOGY | 1995年 / 24卷 / 01期
关键词
HAIR CELLS; HEARING LOSS; INNER EAR; OTOACOUSTIC EMISSIONS; QUININE; SOUND SPECTROGRAPHY;
D O I
10.3109/01050399509042206
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Quinine reversibly affects the outer hair cells (OHC). It is therefore an ideal drug for studying OHC-related phenomena, such as transient evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs). Pure-tone thresholds (PTTs), 1000-4000 Hz, TEOAEs, and DPOAEs were measured monaurally in 5 normal-hearing volunteers during quinine administration. DPOAE was evoked at 75 dB SPL (f(2)/f(1) = 1.22) and analysed at 2f(1)-f(2) with f(2) at 6 frequencies (700-4000 Hz), while TEOAE was obtained at 79 dB SPL(p) and analysed at the f(2) frequencies (1/3 octave). The PTT-shift was flat, 10dB, whereas the TEOAE-power and the global mean of the DPOAEs decreased 4.5 dB and 1.4 dB, respectively. No correlation was found between the intra-individual emission shifts. It is concluded that TEOAE is more sensitive than high-level DPOAE for identifying minor cochlear hearing losses. Support is given to the hypothesis that different sources are involved in generating DPOAEs at different evoking levels.
引用
收藏
页码:27 / 32
页数:6
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