CHARACTERIZATION OF THE NTRK1 GENOMIC REGION INVOLVED IN CHROMOSOMAL REARRANGEMENTS GENERATING TRK ONCOGENES

被引:42
作者
GRECO, A
MARIANI, C
MIRANDA, C
PAGLIARDINI, S
PIEROTTI, MA
机构
[1] Division of Experimental Oncology A, Istituto Nazionale Tumori, 20133 Milan
关键词
D O I
10.1006/geno.1993.1482
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
TRK oncogenes are created by chromosomal rearrangements linking the tyrosine-kinase domain of the NTRK1 gene (encoding one of the receptors for the nerve growth factor) to foreign activating sequences. TRK oncogenes are frequently detected in human papillary thyroid carcinoma, as result of rearrangements involving at least three different activating genes. We have found that the rearrangements creating all the TRK oncogenes so far characterized fall within a 2.9-kb XbaI/SmaI restriction fragment of the NTRK1 gene. Here we report the nucleotide sequence and the exon organization of this fragment. © 1993 Academic Press, Inc.
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页码:397 / 400
页数:4
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