IMMEDIATE RESPONSES IN SERUM TNF-ALPHA AND ACUTE-PHASE PROTEIN CONCENTRATIONS TO INFECTION WITH PASTEURELLA-HAEMOLYTICA A1 IN CALVES

被引：81

作者：

HORADAGODA, A ^{[1
]}

ECKERSALL, PD ^{[1
]}

HODGSON, JC ^{[1
]}

GIBBS, HA ^{[1
]}

MOON, GM ^{[1
]}

机构：

[1] MOREDUN RES INST,EDINBURGH EH17 7JH,MIDLOTHIAN,SCOTLAND

来源：

RESEARCH IN VETERINARY SCIENCE | 1994年 / 57卷 / 01期

关键词：

D O I：

10.1016/0034-5288(94)90094-9

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The concentrations of tumour necrosis factor-alpha (TNF alpha), serum amyloid A (SAA) and haptoglobin were determined in serum samples taken from four calves in the 10 hours after their intra-tracheal inoculation with Pasteurella haemolytica serotype A1. The concentration of haptoglobin did not increase but the concentration of SAA rose progressively from within two hours of inoculation. The concentration of TNF alpha reached a peak in all the animals two hours after inoculation but had returned to undetectable levels after a further four hours. TNF alpha is likely to be an important mediator of the acute phase response in cattle and SAA is a more rapid bovine acute phase protein than haptoglobin in its response to infection with P haemolytica.

引用

页码：129 / 132

页数：4

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