CD4+ CYTOLYTIC T-CELL CLONE CONFERS PROTECTION AGAINST MURINE MALARIA

被引：142

作者：

TSUJI, M ^{[1
]}

ROMERO, P ^{[1
]}

NUSSENZWEIG, RS ^{[1
]}

ZAVALA, F ^{[1
]}

机构：

[1] NYU, SCH MED, DEPT MED & MOLEC PARASITOL, 321 E 45TH ST, NEW YORK, NY 10010 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 05期

关键词：

D O I：

10.1084/jem.172.5.1353

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms ofPlasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-γ and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge. © 1990, Rockefeller University Press., All rights reserved.

引用

页码：1353 / 1357

页数：5

共 16 条

[1] T-CELL REGULATION OF B-CELL ACTIVATION - CLONED LYT-1+2- T SUPPRESSOR CELLS INHIBIT THE MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED INTERACTION OF T-HELPER-CELLS WITH B-CELLS AND OR ACCESSORY CELLS [J].

ASANO, Y ;

HODES, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (04) :1178-1190

[2]

CLARK IA, 1987, J IMMUNOL, V139, P3493

[3] THE EXPRESSION OF I-ED MOLECULES IN F1-HYBRID MICE DETECTED WITH ANTIGEN-SPECIFIC, I-ED-RESTRICTED CLONED T-CELL LINES [J].

CONRAD, PJ ;

JANEWAY, CA .

IMMUNOGENETICS, 1984, 20 (03) :311-319

[4] INHIBITION OF DEVELOPMENT OF EXOERYTHROCYTIC FORMS OF MALARIA PARASITES BY GAMMA-INTERFERON [J].

FERREIRA, A ;

SCHOFIELD, L ;

ENEA, V ;

SCHELLEKENS, H ;

VANDERMEIDE, P ;

COLLINS, WE ;

NUSSENZWEIG, RS ;

NUSSENZWEIG, V .

SCIENCE, 1986, 232 (4752) :881-884

[5] EXPRESSION OF CLASS-I AND CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ON HUMAN HEPATOCYTES [J].

FRANCO, A ;

BARNABA, V ;

NATALI, P ;

BALSANO, C ;

MUSCA, A ;

BALSANO, F .

HEPATOLOGY, 1988, 8 (03) :449-454

[6]

GILLIS S, 1978, J IMMUNOL, V120, P2027

[7] LOW-DOSES OF INTERLEUKIN-2 INDUCE BYSTANDER CELL-LYSIS BY ANTIGEN-SPECIFIC CD4+ INFLAMMATORY T-CELL CLONES IN SHORT-TERM ASSAY [J].

GROMKOWSKI, SH ;

HEPLER, KM ;

JANEWAY, CA .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (09) :1385-1389

[8] RATIONALE FOR THE DEVELOPMENT OF AN ENGINEERED SPOROZOITE MALARIA VACCINE [J].

NUSSENZWEIG, V ;

NUSSENZWEIG, RS .

ADVANCES IN IMMUNOLOGY, 1989, 45 :283-334

[9] CLONED CYTO-TOXIC T-CELLS RECOGNIZE AN EPITOPE IN THE CIRCUMSPOROZOITE PROTEIN AND PROTECT AGAINST MALARIA [J].

ROMERO, P ;

MARYANSKI, JL ;

CORRADIN, G ;

NUSSENZWEIG, RS ;

NUSSENZWEIG, V ;

ZAVALA, F .

NATURE, 1989, 341 (6240) :323-326

[10] GAMMA-INTERFERON, CD8+ T-CELLS AND ANTIBODIES REQUIRED FOR IMMUNITY TO MALARIA SPOROZOITES [J].

SCHOFIELD, L ;

VILLAQUIRAN, J ;

FERREIRA, A ;

SCHELLEKENS, H ;

NUSSENZWEIG, R ;

NUSSENZWEIG, V .

NATURE, 1987, 330 (6149) :664-666

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