AN IMMUNOGENIC ONCHOCERCA-VOLVULUS ANTIGEN - A SPECIFIC AND EARLY MARKER OF INFECTION

被引：132

作者：

LOBOS, E

WEISS, N

KARAM, M

TAYLOR, HR

OTTESEN, EA

NUTMAN, TB

机构：

[1] JOHNS HOPKINS UNIV,WILMER OPHTHALMOL INST,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21205

[3] SWISS TROP INST,CH-4051 BASEL,SWITZERLAND

[4] WHO,ONCHOCERCIASIS CONTROL PROGRAMME,OUAGADOUGOU,BURKINA FASO

来源：

SCIENCE | 1991年 / 251卷 / 5001期

关键词：

D O I：

10.1126/science.2011741

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Onchocerciasis (river blindness) is a serious health problem and a severe obstacle to social and economic development, especially in Africa. A complementary DNA fragment coding for an Onchocerca volvulus antigen (OV-16) was cloned and expressed in the plasmid vector pCG808fx. Immune responses to this O. volvulus-specific recombinant antigen were detectable in patients with documented onchocerciasis; the antibody response was also detectable at 3 months and at more than 1 year before infection could otherwise be detected in humans and in chimpanzees experimentally infected with O. volvulus third-stage larvae.

引用

页码：1603 / 1605

页数：3

共 18 条

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