EFFECTS OF HALOPERIDOL AND SCH 23390 ON ACOUSTIC STARTLE AND PREPULSE INHIBITION UNDER BASAL AND STIMULATED CONDITIONS

被引:47
作者
SCHWARZKOPF, SB
BRUNO, JP
MITRA, T
机构
[1] UNIV ROCHESTER,DEPT PSYCHIAT,ROCHESTER,NY 14650
[2] OHIO STATE UNIV,DEPT PSYCHOL,COLUMBUS,OH 43210
[3] OHIO STATE UNIV,DEPT PSYCHIAT,COLUMBUS,OH 43210
关键词
ACOUSTIC STARTLE REFLEX; BASE-LINE STARTLE; DOPAMINE; D1; RECEPTOR; D2; PREPULSE INHIBITION; SYNERGISM;
D O I
10.1016/0278-5846(93)90028-Q
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. Adult Sprague-Dawley rats underwent startle testing for assessment of baseline startle amplitude and prepulse inhibition (PPI) of the startle reflex. 2. Animals were tested after administration of either: saline, a selective D1 dopamine (DA) receptor antagonist, a relatively selective D2 DA antagonist, or combined low dose D1 and D2 antagonists. 3. Changes due to antagonists were assessed with and without administration of the D1/D2 agonist apomorphine. 4. Testing without apomorphine stimulation showed that both D1 and D2 antagonists reduce baseline startle and enhance PPI. Further, the two antagonists exhibited a synergistic interaction. 5. Testing with apomorphine showed that D1 and D2 antagonists reduce apomorphine-induced startle enhancement. Again, the two exhibited a synergistic interaction. 6. For PPI, the D2 but not D1 antagonist reduced the apomorphine effect. However, the D1 antagonist potentiated the effect of the D2 antagonist.
引用
收藏
页码:1023 / 1036
页数:14
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