STRUCTURAL REQUIREMENTS FOR PEP BINDING TO EPSP SYNTHASE

被引：11

作者：

WALKER, MC

REAM, JE

SAMMONS, RD

LOGUSCH, EW

OLEARY, MH

SOMERVILLE, RL

SIKORSKI, JA

机构：

[1] UNIV NEBRASKA,CTR BIOL CHEM,LINCOLN,NE 68583

[2] PURDUE UNIV,DEPT BIOCHEM,W LAFAYETTE,IN 47907

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)81048-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Evaluation of structural analogs of PEP as inhibitors of EPSP synthase demonstrate that this enzyme displays a high degree of structural and ionic specificity for PEP binding. Both carboxyallenyl phosphate (1) and (Z)-3-fluoro-PEP (5) were surprisingly potent EPSP synthase inhibitors.

引用

页码：683 / 688

页数：6

共 22 条

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