THYROTROPIN-RELEASING HORMONE-LIKE AND GABA-LIKE IMMUNOREACTIVITY COEXIST IN NEURONS IN THE DORSAL HORN OF THE RAT SPINAL-CORD

被引：15

作者：

FLEMING, A ^{[1
]}

TODD, AJ ^{[1
]}

机构：

[1] UNIV GLASGOW,DEPT ANAT,GLASGOW G12 8QQ,SCOTLAND

来源：

BRAIN RESEARCH | 1994年 / 638卷 / 1-2期

基金：

英国惠康基金;

关键词：

GLYCINE; COLOCALIZATION; IMMUNOHISTOCHEMISTRY; PEPTIDE;

D O I：

10.1016/0006-8993(94)90670-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to determine which types of neuron in spinal dorsal horn contain the peptide TRH, pre-embedding immunocytochemistry with antiserum to TRH was combined with post-embedding detection of GABA- and glycine-like immunoreactivity. The majority (88/101) of TRH-immunoreactive neurons were also GABA-immunoreactive, but none were glycine-immunoreactive. This suggests that TRH is mainly present in inhibitory interneurons which release GABA but not glycine, and provides further evidence that there are functional differences between those GABAergic neurons in the superficial dorsal horn that contain glycine, and those that do not.

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页码：347 / 351

页数：5

相关论文

共 22 条

[1] THYROTROPIN-RELEASING-HORMONE IN SPINAL-CORD - COEXISTENCE WITH SEROTONIN AND WITH SUBSTANCE-P IN FIBERS AND TERMINALS APPOSING IDENTIFIED PREGANGLIONIC SYMPATHETIC NEURONS [J].

APPEL, NM ;

WESSENDORF, MW ;

ELDE, RP .

BRAIN RESEARCH, 1987, 415 (01) :137-143

[2] 5-HYDROXYTRYPTAMINE, SUBSTANCE-P, AND THYROTROPIN-RELEASING-HORMONE IN THE ADULT CAT SPINAL-CORD SEGMENT L7 - IMMUNOHISTOCHEMICAL AND CHEMICAL STUDIES [J].

ARVIDSSON, U ;

CULLHEIM, S ;

ULFHAKE, B ;

BENNETT, GW ;

FONE, KCF ;

CUELLO, AC ;

VERHOFSTAD, AAJ ;

VISSER, TJ ;

HOKFELT, T .

SYNAPSE, 1990, 6 (03) :237-270

[3] THYROTROPIN-RELEASING-HORMONE (TRH)-LIKE IMMUNOREACTIVITY IN THE GRAY MONKEY (MACACA-FASCICULARIS) SPINAL-CORD AND MEDULLA-OBLONGATA WITH SPECIAL EMPHASIS ON THE BULBOSPINAL TRACT [J].

ARVIDSSON, U ;

ULFHAKE, B ;

CULLHEIM, S ;

SHUPLIAKOV, O ;

BRODIN, E ;

FRANCK, J ;

BENNETT, GW ;

FONE, KCF ;

VISSER, TJ ;

HOKFELT, T .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 322 (03) :293-310

[4] DISTRIBUTION OF GLYCINE RECEPTOR IMMUNOREACTIVITY IN THE SPINAL-CORD OF THE RAT - CYTOCHEMICAL EVIDENCE FOR A DIFFERENTIAL GLYCINERGIC CONTROL OF LAMINA-I AND LAMINA-V NOCICEPTIVE NEURONS [J].

BASBAUM, AI .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 278 (03) :330-336

[5]

COFFIELD JA, 1986, J NEUROSCI, V6, P1194

[6] DIFFERENTIAL-EFFECTS OF INTRACEREBROVENTRICULAR COLCHICINE ADMINISTRATION ON THE EXPRESSION OF MESSENGER-RNAS FOR NEUROPEPTIDES AND NEUROTRANSMITTER ENZYMES, WITH SPECIAL EMPHASIS ON GALANIN - AN INSITU HYBRIDIZATION STUDY [J].

CORTES, R ;

CECCATELLI, S ;

SCHALLING, M ;

HOKFELT, T .

SYNAPSE, 1990, 6 (04) :369-391

[7] A THYROTROPIN-RELEASING HORMONE-CONTAINING SYSTEM IN THE RAT DORSAL HORN SEPARATE FROM SEROTONIN [J].

HARKNESS, DH ;

BROWNFIELD, MS .

BRAIN RESEARCH, 1986, 384 (02) :323-333

[8] THYROTROPIN RELEASING HORMONE (TRH)-CONTAINING NERVE-TERMINALS IN CERTAIN BRAIN-STEM NUCLEI AND IN SPINAL-CORD [J].

HOKFELT, T ;

FUXE, K ;

JOHANSSON, O ;

JEFFCOATE, S ;

WHITE, N .

NEUROSCIENCE LETTERS, 1975, 1 (03) :133-139

[9] THYROTROPIN RELEASING HORMONE (TRH) MODIFIES EXCITABILITY OF SPINAL-CORD DORSAL HORN CELLS [J].

JACKSON, DA ;

WHITE, SR .

NEUROSCIENCE LETTERS, 1988, 92 (02) :171-176

[10] IMMUNOHISTOCHEMICAL SUPPORT FOR 3 PUTATIVE TRANSMITTERS IN ONE NEURON - COEXISTENCE OF 5-HYDROXYTRYPTAMINE, SUBSTANCE P-LIKE AND THYROTROPIN RELEASING HORMONE-LIKE IMMUNOREACTIVITY IN MEDULLARY NEURONS PROJECTING TO THE SPINAL-CORD [J].

JOHANSSON, O ;

HOKFELT, T ;

PERNOW, B ;

JEFFCOATE, SL ;

WHITE, N ;

STEINBUSCH, HWM ;

VERHOFSTAD, AAJ ;

EMSON, PC ;

SPINDEL, E .

NEUROSCIENCE, 1981, 6 (10) :1857-1881