CELL-INTERACTIONS THAT DETERMINE SYMPATHETIC NEURON TRANSMITTER PHENOTYPE AND THE NEUROKINES THAT MEDIATE THEM

被引:61
作者
RAO, MS [1 ]
LANDIS, SC [1 ]
机构
[1] CASE WESTERN RESERVE UNIV, SCH MED, DEPT NEUROSCI, CLEVELAND, OH 44106 USA
来源
JOURNAL OF NEUROBIOLOGY | 1993年 / 24卷 / 02期
关键词
SYMPATHETIC NEURON TRANSMITTER PHENOTYPE; TRANSMITTER PLASTICITY; NEURAL CREST; NEUROPEPTIDE REGULATION; CILIARY NEUROTROPHIC FACTOR; LEUKEMIA INHIBITORY FACTOR;
D O I
10.1002/neu.480240208
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The transmitter properties of both developing and mature sympathetic neurons are plastic and can be modulated by a number of environmental cues. Cell culture studies demonstrate that noradrenergic neurons can be induced to become cholinergic and that the expression of neuropeptides can be altered. Similar changes in transmitter phenotype occur in vivo. During development, noradrenergic neurons that innervate eccrine sweat glands acquire cholinergic and peptidergic function. This change is dependent upon interactions with the target tissue. Following injury of sympathetic neurons in developing and adult animals, striking alterations take place in peptide expression. Ciliary neurotrophic factor and cholinergic differentiation factor/leukemia inhibitory factor, members of a family that includes several hematopoeitic cytokines, induce cholinergic function and modulate neuropeptide expression in cultured sympathetic neurons. Studies in progress provide evidence that members of this new cytokine family influence the transmitter phenotype of sympathetic neurons not only in vitro but also in vivo.
引用
收藏
页码:215 / 232
页数:18
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