ALLOIMMUNIZATION DURING PREGNANCY - CLINICAL-RESULTS FROM 1983 TO 1989 IN A SCANDINAVIAN-UNIVERSITY-HOSPITAL

被引:6
作者
BELFRAGE, P
THOMASSEN, P
FLOBERG, J
AKERBLOM, O
BROBERGER, U
机构
[1] KAROLINSKA HOSP, DEPT PEDIAT, S-10401 STOCKHOLM 60, SWEDEN
[2] KAROLINSKA HOSP, CTR BLOOD, S-10401 STOCKHOLM 60, SWEDEN
关键词
ALLOIMMUNIZATION; ERYTHROCYTE ANTIGENS; AMNIOCENTESIS; HYDROPS-FETALIS; INTRAUTERINE TRANSFUSION; EXCHANGE TRANSFUSION;
D O I
10.3109/00016349209021051
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
From 1983 to 1989, 147,068 pregnancies were analyzed for allo-immunization against erythrocyte antigens. Approximately half of the cases were due to immunization against factor D and the others were due to allo-immunization against other antigens (K, c, E, etc.). In 61 cases exchange transfusion of the newborn was needed and in 115 cases diagnostic amniocentesis was done during pregnancy. Intrauterine transfusions were performed in 10 cases. Fetal and neonatal mortality was 4% in these moderate to severe cases, all due to immunization against D. Immunization against D was due to failure to give immunoglobulin anti-D in about 2/3 of the cases. Systematic prophylactic treatment with anti-D during pregnancy would probably not be cost-effective in this population.
引用
收藏
页码:273 / 277
页数:5
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