P53 IN COLORECTAL-CANCER - CLINICOPATHOLOGICAL CORRELATION AND PROGNOSTIC-SIGNIFICANCE

被引：262

作者：

SCOTT, N

SAGAR, P

STEWART, J

BLAIR, GE

DIXON, MF

QUIRKE, P

机构：

[1] UNIV LEEDS,DEPT SURG,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

[2] UNIV LEEDS,DEPT BIOCHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 02期

关键词：

D O I：

10.1038/bjc.1991.74

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

p53 protein was detected by immunohistochemistry in 42% of 52 colorectal adenocarcinomas. Positive tumours were significantly more frequent in the distal colon, and demonstrated a higher rate of cell proliferation. No correlation was found with tumour grade, Duke's stage, presence of DNA aneuploidy or patient survival. The role of p53 in colorectal carcinogenesis is discussed with particular reference to differences between proximal and distal large bowel cancers.

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收藏

页码：317 / 319

页数：3

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