BACLOFEN IN THE TREATMENT OF IDIOPATHIC DYSTONIA IN CHILDREN

被引：47

作者：

GREENE, PE ^{[1
]}

FAHN, S ^{[1
]}

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR,INST NEUROL,DYSTONIA CLIN RES CTR,NEW YORK,NY 10032

来源：

MOVEMENT DISORDERS | 1992年 / 7卷 / 01期

关键词：

BACLOFEN; IDIOPATHIC DYSTONIA; CHILDREN;

D O I：

10.1002/mds.870070109

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Baclofen benefits some patients with adult onset dystonia, but few reports document the response to baclofen of children with idiopathic dystonia. Sixteen of 80 patients < age 21 years with idiopathic dystonia seen by the Movement Disorder Group at Columbia-Presbyterian Medical Center in New York were treated with baclofen. Five had substantial improvement in symptoms, two had moderate improvement, and nine failed to benefit. Three of the improved patients had transient improvement on high dose anticholinergics, but had sustained, dramatic improvement when baclofen was added. At last follow-up, five patients maintained improvement for a mean 3.8 years (19 months-8 years) on a mean 79 mg of baclofen (40-120 mg). Response to baclofen did not correlate with age at onset of dystonia or age at onset of therapy, but did correlate with duration of symptoms before therapy (3 years for those who improved vs 7.8 years for those who did not: p < .002 by t-test). Baclofen can be an effective treatment for childhood dystonia.

引用

页码：48 / 52

页数：5

共 15 条

[1]

Davidoff RA., Antispasticity drugs: mechanisms of action, Ann Neurol, 17, pp. 107-116, (1985)

[2]

Yassa R, Nair V, Dimitry R., Prevalence of tardive dystonia, Acta Psychiatr Scand, 73, pp. 629-633, (1986)

[3]

Rosse RB, Allen A, Lux WE., Baclofen treatment in a patient with tardive dystonia, J Clin Psychiatr, 47, pp. 474-475, (1986)

[4]

Lees AJ, Shaw KM, Stern GM., Baclofen in Parkinson's disease, J Neurol Neurosurg Psychiatry, 41, pp. 707-708, (1978)

[5]

Nausieda PA, Weiner WJ, Klawans HL., Dystonic foot response of Parkinsonism, Arch Neurol, 37, pp. 132-136, (1980)

[6]

Brandt NJ, Gregersen N, Christensen E, Gron IH, Rasmussen K., Treatment of glutaryl‐CoA dehydrogenase deficiency (glutaric aciduria). Experience with diet, riboflavin and GABA analogue, J Pediatr, 94, pp. 669-673, (1979)

[7]

Gollomp SM, Fahn S, Burke RE, Reches A, Ilson J., Therapeutic trials in Meige syndrome, Adv Neurol, 37, pp. 207-213, (1983)

[8]

Greene P, Shale H, Fahn S., Analysis of open‐label trials in torsion dystonia using high dosages of anticholinergics and other drugs, Mov Disord, 3, pp. 46-60, (1988)

[9]

Fahn S, Hening WA, Bressman S, Burke R, Ilson J, Walters A., Long‐term usefulness of baclofen in the treatment of essential blepharospasm, Adv Ophthal Plast Reconst Surg, 4, pp. 219-226, (1985)

[10]

Milla PJ, Jackson ADM., A controlled trial of baclofen in children with cerebral palsy, Int Med Res, 5, pp. 398-404, (1977)

← 1 2 →