ALZHEIMER PLAQUE DENSITY AND DURATION OF DEMENTIA

被引：8

作者：

BEER, RE ^{[1
]}

ULRICH, J ^{[1
]}

机构：

[1] UNIV BASEL,INST PATHOL,DIV NEUROPATHOL,SCHONBEINSTR 40,CH-4003 BASEL,SWITZERLAND

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1993年 / 16卷 / 01期

关键词：

ALZHEIMER; SENILE PLAQUE; AMYLOID; DENSITY; BETA-A4; PROTEIN; MORPHOLOGICAL EVOLUTION;

D O I：

10.1016/0167-4943(93)90021-9

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Thirty-two post-mortem Alzheimer cases with known duration of dementia were studied. Senile plaques (SP) in the neocortex and entorhinal cortex adjacent to the right hippocampus were stained with an antiserum to A4-beta-protein, which is specific for the amyloid protein and detects all plaque types including the amyloid-sparse diffuse plaques. The total number of SP per mm2 of neocortex was significantly correlated to the duration of dementia (P < 0.01). The total of beta-A4 stained tissue per mm2 neocortex was also correlated to the duration of dementia (P < 0.05). Our results support the assumption that more and more plaques form during the course of Alzheimer's disease and that they either disappear more slowly than they are generated or that they persist once they are formed.

引用

页码：1 / 7

页数：7

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