ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
|
1993年
/
55卷
/
02期
关键词:
NOSE DROPS;
ALPHA-ADRENOCEPTOR AGONISTS;
LASER-DOPPLER;
VASOMOTION;
D O I:
10.1159/000276392
中图分类号:
R76 [耳鼻咽喉科学];
学科分类号:
100213 ;
摘要:
Periodic oscillations of blood in the microcirculation of the sinus mucosa in the rabbit were studied with laser-Doppler flowmetry after the application of nose drops (oxymetazoline, xylometazoline and phenylephrine) to the nasal mucosa. All of these drugs induced a dose-dependent decrease in the blood flow in the mucosa. Flowmotion was found in 9 of 21 experiments after an approximately 50% reduction in blood flow had been induced. The concentrations of the drugs which caused vasomotion corresponded to those normally administered as nose drops to man.