NOSE DROPS INDUCE VASOMOTION IN THE MICROCIRCULATION OF THE SINUS MUCOSA OF THE RABBIT

被引:2
作者
BENDE, M [1 ]
ARFORS, KE [1 ]
INTAGLIETTA, M [1 ]
机构
[1] UNIV CALIF SAN DIEGO,DEPT APPL MECH & ENGN SCI BIOENGN,LA JOLLA,CA 92093
来源
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1993年 / 55卷 / 02期
关键词
NOSE DROPS; ALPHA-ADRENOCEPTOR AGONISTS; LASER-DOPPLER; VASOMOTION;
D O I
10.1159/000276392
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Periodic oscillations of blood in the microcirculation of the sinus mucosa in the rabbit were studied with laser-Doppler flowmetry after the application of nose drops (oxymetazoline, xylometazoline and phenylephrine) to the nasal mucosa. All of these drugs induced a dose-dependent decrease in the blood flow in the mucosa. Flowmotion was found in 9 of 21 experiments after an approximately 50% reduction in blood flow had been induced. The concentrations of the drugs which caused vasomotion corresponded to those normally administered as nose drops to man.
引用
收藏
页码:110 / 113
页数:4
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