NEOADJUVANT CISPLATIN, METHOTREXATE AND VINBLASTINE FOR MUSCLE-INVASIVE BLADDER-CANCER - LONG-TERM FOLLOW-UP

被引：17

作者：

DREICER, R

KOLLMORGEN, TA

SMITH, RF

WILLIAMS, RD

机构：

[1] Department of Urology, Iowa University College of Medicine, Iowa City, IA

来源：

JOURNAL OF UROLOGY | 1993年 / 150卷 / 03期

关键词：

BLADDER NEOPLASMS; CISPLATIN; METHOTREXATE; VINBLASTINE; DRUG THERAPY;

D O I：

10.1016/S0022-5347(17)35630-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A total of 26 patients with locally advanced bladder cancer received chemotherapy consisting of cisplatin, methotrexate and vinblastine. Radical cystectomy was performed in 24 of 26 patients (92%) receiving neoadjuvant therapy, with a pathological complete response in 6 (23%) and pathological partial response in 1 (4%) for an overall response rate of 35% (95% confidence limits 17 to 56%). The overall median survival time is currently undefined. Of the patients 15 (58%) are alive with a median followup of 48.6 months. Response rates from this neoadjuvant chemotherapy appear to be similar to those reported with methotrexate, vinblastine, doxorubicin and cisplatin, and may represent a therapeutically equivalent regimen but neither may be curative in the majority of the patients.

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页码：849 / 852

页数：4

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