INFLUENCE OF THE STRUCTURE OF SUPPORT MICROSPHERES ON LEUKOCYTE ACTIVATION BY RGDS-CARRYING MICROSPHERES

被引：4

作者：

KASUYA, Y

FUJIMOTO, K

KAWAGUCHI, H

MIYAMOTO, M

机构：

[1] KEIO UNIV, FAC SCI & TECHNOL, DEPT APPL CHEM, KOHOKU KU, YOKOHAMA, KANAGAWA 223, JAPAN

[2] JAPANESE RED CROSS, CTR CENT BLOOD, DEPT RES, SHIBUYA KU, TOKYO 150, JAPAN

来源：

BIOMATERIALS | 1994年 / 15卷 / 08期

关键词：

MICROSPHERES; CELL ADHESION; POLYMORPHONUCLEAR LEUKOCYTES; PHAGOCYTOSIS;

D O I：

10.1016/0142-9612(94)90206-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A cell adhesive peptide, Arg-Gly-Asp-Ser (RGDS), enhances leucocyte response to stimuli when insolubilized or conjugated with proteins. In order to investigate the contribution of the microsphere structure to leucocyte response, RGDS was immobilized onto several polymeric microspheres. The respiratory burst of polymorphonuclear leucocytes (PMNs) contacting microspheres was enhanced by RGDS in cases where it was immobilized on polystyrene and, more effectively, a positively charged one. This was not observed in polyacrylamide-based or negative-charged microsphere systems. These results demonstrate that the property of supports strongly affects the regulation of the PMN response via an adhesive interaction.

引用

页码：570 / 576

页数：7

共 26 条

[1] MICROSPHERES FOR BIOMEDICAL APPLICATIONS - PREPARATION OF REACTIVE AND LABELED MICROSPHERES [J].