THE EFFECTS OF THE SPECIFIC UPTAKE INHIBITOR LU 10-171 (CITALOPRAM) UPON BRAIN INDOLEAMINE STORES IN THE MATURING MOUSE

被引：14

作者：

BAKER, PC ^{[1
]}

GOODRICH, CA ^{[1
]}

机构：

[1] CLEVELAND STATE UNIV, DEPT BIOL, CLEVELAND, OH 44115 USA

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1982年 / 13卷 / 01期

关键词：

D O I：

10.1016/0306-3623(82)90013-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The specific 5-HT [serotonin] uptake inhibitor Lu 10-171 (Citalopram) was used to test uptake inhibition and reduced turnover in maturing mouse brain. All ages showed 5-hydroxyindoleacetic acid elevation indicative of inhibition and reduced turnover. Enzymatic blockade in conjunction with Lu 10-171 supported the evidence for reduced turnover. The significance of early serotonergic maturation is discussed.

引用

页码：59 / 61

页数：3

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