ANGIOTENSIN-II MONOCLONAL-ANTIBODY - BLOOD-PRESSURE EFFECTS IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

被引：15

作者：

WONG, PC

REILLY, TM

TIMMERMANS, PBMWM

机构：

[1] Medical Products Department, Pharmaceutical Research Division, E.I. du Pont de Nemours and Company, Wilmington, DE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 186卷 / 2-3期

关键词：

Angiotensin II receptor antagonists; Antihypertensive agents; Blood pressure; Monoclonal antibody; Spontaneously hypertensive rats (SHR);

D O I：

10.1016/0014-2999(90)90460-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The angiotensin II (AII) specific monoclonal antibody KAA8 - a selective functional AII antagonist and a hypotensive agent in high renin hypertensive rats - did not lower blood pressure in conscious normotensive rats (NRs) and spontaneously hypertensive rats (SHRs). The non-peptide AII receptor antagonist DuP 753 decreased blood pressure significantly in SHRs but not in NRs. These results suggest the involvement of locally released AII in the control of blood pressure in SHRs but not in NRs. © 1990.

引用

页码：353 / 356

页数：4

共 10 条

[1] SIGNIFICANCE OF THE VASCULAR RENIN-ANGIOTENSIN PATHWAY [J].

DZAU, VJ .

HYPERTENSION, 1986, 8 (07) :553-559

[2] PHARMACOLOGIC INTERRUPTION OF THE RENIN-ANGIOTENSIN SYSTEM [J].

HOLLENBERG, NK .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1979, 19 :559-582

[3] BETA-ADRENOCEPTOR-MEDIATED RELEASE OF ANGIOTENSIN-II FROM MESENTERIC-ARTERIES [J].

NAKAMARU, M ;

JACKSON, EK ;

INAGAMI, T .

AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (01) :H144-H148

[4]

REILLY TM, 1988, J PHARMACOL EXP THER, V244, P160

[5] COMPARISON OF ANGIOTENSIN-II ANTAGONIST AND ANTISERUM INFUSION WITH NEPHRECTOMY IN RAT WITH 2-KIDNEY GOLDBLATT HYPERTENSION [J].

THURSTON, H ;

SWALES, JD .

CIRCULATION RESEARCH, 1974, 35 (02) :325-329

[6]

WONG PC, 1989, J PHARMACOL EXP THER, V250, P515

[7]

WONG PC, 1990, J PHARMACOL EXP THER, V252, P726

[8]

WONG PC, 1989, HYPERTENSION, V14, P448

[9]

WONG PC, 1990, HYPERTENSION, V15, P495

[10] MONOCLONAL-ANTIBODIES AND NONPEPTIDE ANTAGONISTS TO ANGIOTENSIN-II - POTENTIAL IMPLICATIONS [J].

ZIMMERMAN, BG .

HYPERTENSION, 1989, 14 (05) :498-500

← 1 →