DNA ADDUCTS DETECTED BY P-32 POSTLABELING, IN THE INTESTINE OF RATS GIVEN BILE FROM PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS AND FROM UNAFFECTED CONTROLS

被引：25

作者：

SCATES, DK

SPIGELMAN, AD

PHILLIPS, RKS

VENITT, S

机构：

[1] ROYAL MARSDEN HOSP,INST CANC RES,HADDOW LABS,CANC RES CAMPAIGN SECT MOLEC CARCINOGENESIS,SUTTON SM2 5NG,SURREY,ENGLAND

[2] ST MARKS HOSP,LONDON EC1V 2PS,ENGLAND

[3] ST BARTHOLOMEWS HOSP,PROFESSORIAL SURG UNIT,LONDON EC1,ENGLAND

[4] ST MARYS HOSP,ACAD SURG UNIT,LONDON,ENGLAND

来源：

CARCINOGENESIS | 1992年 / 13卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/carcin/13.4.731

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Duodenal adenomas are common in patients with familial adenomatous polyposis (FAP) and cluster around the papilla, suggesting the involvement of bile in their development. Using P-32-postlabelling we determined levels of DNA adducts in the small bowel and colon of rats treated with bile from FAP and control patients. We found a significantly higher level of adducts in the small bowel of rats treated with FAP gallbladder bile compared with control gallbladder bile (P = 0.0034). This result supports the hypothesis that bile plays a role in the development of neoplasia in the foregut of FAP patients.

引用

页码：731 / 735

页数：5

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