MUTATIONS IN T-CELL ANTIGEN RECEPTOR GENES ALPHA-BLOCK AND BETA-BLOCK THYMOCYTE DEVELOPMENT AT DIFFERENT STAGES

被引：999

作者：

MOMBAERTS, P

CLARKE, AR

RUDNICKI, MA

IACOMINI, J

ITOHARA, S

LAFAILLE, JJ

WANG, LL

ICHIKAWA, Y

JAENISCH, R

HOOPER, ML

TONEGAWA, S

机构：

[1] MIT,CTR CANC RES,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02139

[2] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[3] UNIV EDINBURGH,AFRC,CTR GENOME RES,EDINBURGH EH8 9AG,MIDLOTHIAN,SCOTLAND

[4] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

[5] UNIV EDINBURGH,DEPT PATHOL,CANC RES CAMPAIGN LABS,EDINBURGH EH8 9AG,MIDLOTHIAN,SCOTLAND

来源：

NATURE | 1992年 / 360卷 / 6401期

关键词：

D O I：

10.1038/360225a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gammadelta T cells does not depend on either TCR-alpha or TCR-beta.

引用

页码：225 / 231

页数：7

共 29 条

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