SCREENING-TEST OF CRUDE DRUG EXTRACT ON ANTI-HIV ACTIVITY

被引：29

作者：

YAMASAKI, K ^{[1
]}

OTAKE, T ^{[1
]}

MORI, H ^{[1
]}

MORIMOTO, M ^{[1
]}

UEBA, N ^{[1
]}

KUROKAWA, Y ^{[1
]}

SHIOTA, K ^{[1
]}

YUGE, T ^{[1
]}

机构：

[1] OSAKA UNIV PHARMACEUT SCI, MATSUBARA, OSAKA 580, JAPAN

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1993年 / 113卷 / 11期

关键词：

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1); ANTIVIRAL ACTIVITY; AIDS; CRUDE DRUG EXTRACT; LITHOSPERMUM ERYTHRORHIZON; PRUNELLA VULGARIS;

D O I：

10.1248/yakushi1947.113.11_818

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 mu g/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.

引用

页码：818 / 824

页数：7

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