CLARITHROMYCIN CARBAMAZEPINE INTERACTION - A CASE-REPORT

被引：44

作者：

ALBANI, F

RIVA, R

BARUZZI, A

机构：

[1] Laboratory of Neuropharmacology, Institute of Neurology, University of Bologna, Bologna

来源：

EPILEPSIA | 1993年 / 34卷 / 01期

关键词：

CLARITHROMYCIN; MACROLIDE ANTIBIOTICS; ANTICONVULSANTS; CARBAMAZEPINE; CARBAMAZEPINEEPOXIDE; DRUG TOXICITY; DRUG INTERACTIONS;

D O I：

10.1111/j.1528-1157.1993.tb02391.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin. and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10-day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ-E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.

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页码：161 / 162

页数：2

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