BENEFICIAL-EFFECTS OF MYRISTIC, STEARIC OR OLEIC-ACID AS PART OF LIPOSOMES ON EXPERIMENTAL-INFECTION AND ANTITUMOR EFFECT IN A MURINE MODEL

Liposomes consisting of dicetyl-phosphate, cholesterol, lecithin and stearic or myristic or oleic acid, exert a protective effect for mice against experimental infection by Salmonella typhimurium, and delay both the onset and mortality B16 melanoma in these animals. Liposomes labelled with H-3-myristic acid were used as probes in the spleen and liver. We found that the treatment schedule rather than route of administration of liposomes, is important. The results show that in order to induce protection, preventive treatment must start at least three days before. Longer treatments do not increase the degree of protection, and treatments started at the same time as or following experimental infection or tumor transplantation, have no effect.