Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells

被引：43

作者：

Duval, Florent ^{[1
]}

Moreno-Cuevas, Jorge E. ^{[1
]}

Teresa Gonzalez-Garza, Maria ^{[1
]}

Rodriguez-Montalvo, Carlos ^{[2
]}

Elva Cruz-Vega, Delia ^{[1
]}

机构：

[1] Escuela Med Tecnol Monterrey, Catedra Terapia Celular, Ave Morones Prieto 3000 Pte, Monterrey 64710, NL, Mexico

[2] Hosp San Jose, Ctr Enferrnedades Hepat Digest Nutr, Monterrey 64710, NL, Mexico

来源：

ADVANCES IN PHARMACOLOGICAL SCIENCES | 2014年 / 2014卷

关键词：

D O I：

10.1155/2014/373295

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. This review will describe the role of hepatocytes and HSC in the pathogenesis of liver fibrosis and detail the mechanisms of modulation of apoptosis of both cell lines by twelve known hepatoprotective plants in order to reduce liver fibrosis.

引用

页数：11

共 99 条

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