MM 47761 AND MM 49721, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF AMYCOLATOPSIS-ORIENTALIS - ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION

被引：14

作者：

BOX, SJ ^{[1
]}

ELSON, AL ^{[1
]}

GILPIN, ML ^{[1
]}

WINSTANLEY, DJ ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,CHEMOTHERAPEUT RES CTR,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 08期

关键词：

D O I：

10.7164/antibiotics.43.931

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two glycopeptide antibiotics MM 47761 and MM 49721 have been isolated from Amycolatopsis orientalis NCIB 12608. Fermentation conditions for their production, and methods for their isolation are described. The metabolites have been characterised by physico-chemical and biological properties and the structure determined by a combination of chemical degradation, COSY and NOE NMR studies. Both metabolites showed good antibacterial activity against Gram-positive organisms. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：931 / 937

页数：7

共 8 条

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