ANTI-TUMOR-PROMOTING ACTIVITY OF DERIVATIVES OF ABIESLACTONE, A NATURAL TRITERPENOID ISOLATED FROM SEVERAL ABIES GENUS

被引：43

作者：

TAKAYASU, J

TANAKA, R

MATSUNAGA, S

UEYAMA, H

TOKUDA, H

HASEGAWA, T

NISHINO, A

NISHINO, H

IWASHIMA, A

机构：

[1] OSAKA UNIV PHARMACEUT SCI,OSAKA 580,JAPAN

[2] SHIGA UNIV MED SCI,OTSU,SHIGA 52021,JAPAN

来源：

CANCER LETTERS | 1990年 / 53卷 / 2-3期

关键词：

abieslactone; anti-inflammation; anti-tumor-promotion;

D O I：

10.1016/0304-3835(90)90206-D

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abiesenonic acid methyl ester (AVB-I acid methyl ester), a triterpenoid compound prepared from abieslactone, suppressed tumor promoter-induced phenomena in vitro and in vivo; i.e., AVB-I acid methyl ester inhibited 12-o-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells and the promoting action of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. © 1990.

引用

页码：141 / 144

页数：4

共 9 条

[1] CRYSTAL AND MOLECULAR-STRUCTURE OF ABIESLACTONE, (23R)-3-ALPHA-METHOXY-5ALPHA,9BETA-IANOSTA-7,24-DIENE-26,23-LACTONE [J].