CONDITIONAL POWER FOR ARBITRARY SURVIVAL CURVES TO DECIDE WHETHER TO EXTEND A CLINICAL-TRIAL

被引:13
作者
HENDERSON, WG
FISHER, SG
WEBER, L
HAMMERMEISTER, KE
SETHI, G
机构
[1] VET ADM MED CTR,DEPT CARDIOL,DENVER,CO 80220
[2] VET ADM MED CTR,DEPT CARDIOTHORAC SURG,TUCSON,AZ 85723
来源
CONTROLLED CLINICAL TRIALS | 1991年 / 12卷 / 02期
关键词
CONDITIONAL POWER; SURVIVAL ANALYSIS; ARBITRARY SURVIVAL CURVES;
D O I
10.1016/0197-2456(91)90027-J
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This article describes a computer simulation methodology to calculate conditional power for comparing two arbitrary survival curves as an aid in deciding whether or not to extend a clinical trial. The method is a modification of that by Halpern and Brown, which computes unconditional power for comparing arbitrary survival curves at the beginning of a study. The advantage of this method is that it permits conditional power calculations for comparisons of distribution-free survival curves. Power is computed for two commonly used statistical tests, the log-rank test and Gehan's generalization of the Wilcoxon test, and for a modified Kolmogorov-Smirnov test, which is particularly sensitive to crossing survival curves. This method for estimating conditional power should be useful in the situation in which a decision must be made regarding the benefit of continuing a clinical trial. The application of this method is shown using VA cooperative Study No. 90, "Prognosis and Outcome Following Heart Valve Replacement."
引用
收藏
页码:304 / 313
页数:10
相关论文
共 13 条
[1]  
ANDERSEN PK, 1987, CONTROL CLIN TRIALS, V8, P67
[2]   10-YEAR ANALYSIS OF THE BJORK-SHILEY STANDARD AORTIC-VALVE [J].
BORKON, AM ;
SOULE, L ;
BAUGHMAN, KL ;
AOUN, H ;
GARDNER, TJ ;
WATKINS, L ;
BAUMGARTNER, WA ;
GOTT, VL ;
REITZ, BA .
ANNALS OF THORACIC SURGERY, 1987, 43 (01) :39-51
[3]   MODIFIED KOLMOGOROV-SMIRNOV TEST PROCEDURES WITH APPLICATION TO ARBITRARILY RIGHT-CENSORED DATA [J].
FLEMING, TR ;
OFALLON, JR ;
OBRIEN, PC .
BIOMETRICS, 1980, 36 (04) :607-625
[4]   SURVIVAL AND EVENT-FREE ANALYSIS OF 785 PATIENTS WITH BJORK-SHILEY SPHERICAL-DISC VALVES AT 10 TO 16 YEARS [J].
FLEMMA, RJ ;
MULLEN, DC ;
KLEINMAN, LH ;
WERNER, PH ;
ANDERSON, AJ ;
WEIRAUCH, E .
ANNALS OF THORACIC SURGERY, 1988, 45 (03) :258-272
[5]   INTRINSIC FAILURE OF HANCOCK MITRAL BIOPROSTHESES - 10-YEAR TO 15-YEAR EXPERIENCE [J].
FOSTER, AH ;
GREENBERG, GJ ;
UNDERHILL, DJ ;
MCINTOSH, CL ;
CLARK, RE .
ANNALS OF THORACIC SURGERY, 1987, 44 (06) :568-577
[6]   INCIDENCE OF PRIMARY TISSUE VALVE FAILURE IN PORCINE BIOPROSTHETIC HEART-VALVES [J].
GALLO, I ;
NISTAL, F ;
BLASQUEZ, R ;
ARBE, E ;
ARTINANO, E .
ANNALS OF THORACIC SURGERY, 1988, 45 (01) :66-70
[7]   LONG-TERM OUTCOME OF CARDIAC-VALVE SUBSTITUTES [J].
GEHA, AS .
ANNALS OF THORACIC SURGERY, 1987, 44 (06) :566-567
[8]   DESIGNING CLINICAL-TRIALS WITH ARBITRARY SPECIFICATION OF SURVIVAL FUNCTIONS AND FOR THE LOG RANK OR GENERALIZED WILCOXON TEST [J].
HALPERN, J ;
BROWN, BW .
CONTROLLED CLINICAL TRIALS, 1987, 8 (03) :177-189
[9]  
LINDBLOM D, 1988, J THORAC CARDIOV SUR, V95, P658
[10]  
LINDBLOM D, 1988, J THORAC CARDIOV SUR, V95, P321