AUTOANTIBODY FORMATION AFTER BONE-MARROW TRANSPLANTATION - A COMPARISON BETWEEN AUTOLOGOUS AND ALLOGENEIC GRAFTS

被引：21

作者：

SANMARCO, M

VIALETTES, B

MARANINCHI, D

BERNARD, D

机构：

[1] Laboratoire d'Immunologic Facullé de Médecine, 13385, Marseille, Cédex 5

[2] Service de Médecine Interne, Hôpital de la Timone, 13385, Marseille, Cédex 5, 254, Rue St-Pierre

[3] Centre de Greffe de Moelle Osseuse, Institut J, 13277, Marseille, Cédex 9, Paoli-1. Calmettes, Bd de Ste Marguerite

来源：

AUTOIMMUNITY | 1991年 / 11卷 / 01期

关键词：

BONE MARROW TRANSPLANTATION; AUTOANTIBODIES;

D O I：

10.3109/08916939108994702

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Various autoantibodies were screened in 11 allogeneic, 14 autologous bone marrow transplanted patients and 11 healthy controls. Except anti-mitochondria antibodies, autoantibodies were found with similar frequencies after allogeneic and autologous transplantation. Moreover, 50% of autoantibodies were already present before transplantation. These results suggest that factors other than allogeneic reaction could be responsible for autoantibody formation after bone marrow transplantation, in particular, pre-graft conditioning treatment and/or viral and bacterial infection. Nevertheless, the number of patients with 2 or more autoantibodies was significantly higher after allogeneic than after autologous grafting (respectively, 82% and 36.7%; P<0.05). Forty percent of allografted but none of autografted patients were still positive at 12 months post graft. So, allogeneic reaction could play a role in intensity of humoral response and its maintenance for a long period. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：7 / 12

页数：6

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