AUTOLOGOUS BLOOD STEM-CELL GRAFTING IN HEMATOLOGICAL MALIGNANCIES - PRESENT STATUS AND FUTURE-DIRECTIONS

被引：11

作者：

REIFFERS, J

MARIT, G

VEZON, G

CONYMAKHOUL, P

BOIRON, JM

MONTASTRUC, M

RICE, A

BROUSTET, A

机构：

[1] Bone Marrow Transplant Unit, CHR Bordeaux, Hôpital Haut-Levêque

[2] Laboratory of Bone Marrow Transplantation. URA CNRS 1456, Université de Bordeaux II

来源：

TRANSFUSION SCIENCE | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1016/0955-3886(92)90024-B

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been demonstrated that peripheral blood stem cells (PBSC) are able to reconstitute hematopoiesis as well as bone marrow cells. This review discusses the possible advantages of PBSC transplantation over autologous bone marrow transplantation (ABMT) including both the kinetics of hematopoietic reconstitution and the outcome of the patients following transplantation. The main advantage of PBSC transplantation is the very short aplastic phase observed after transplantation leading to a decrease of morbidity or even mortality. However, the administration of hematopoietic growth factors after bone marrow transplantation is followed by a reduction in the length of aplasia similar to that expected after PBSC transplantation. In patients with hematological malignancies, the risk of relapse seems to be equivalent after either PBSC transplantation or ABMT. Thus, the future place of PBSC transplantation must be further investigated.

引用

页码：399 / 405

页数：7

共 28 条

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