SITE-DIRECTED MUTAGENESIS OF PENICILLIN-BINDING PROTEIN-3 OF ESCHERICHIA-COLI - ROLE OF VAL-545

被引：4

作者：

AYALA, J ^{[1
]}

GOFFIN, C ^{[1
]}

NGUYENDISTECHE, M ^{[1
]}

GHUYSEN, JM ^{[1
]}

机构：

[1] UNIV LIEGE,INST CHIM,CTR INGN PROT,B-4000 SART,BELGIUM

来源：

FEMS MICROBIOLOGY LETTERS | 1994年 / 121卷 / 02期

关键词：

PENICILLIN-BINDING PROTEIN; ESCHERICHIA COLI CELL SEPTATION; SITE-DIRECTED MUTAGENESIS;

D O I：

10.1111/j.1574-6968.1994.tb07106.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Val545 of the Escherichia coli penicillin-binding protein 3 is essential to the acyl transfer mechanism through which the active-site serine 307 is acylated by benzylpenicillin and cephalexin and to the mechanism through which the protein allows rapidly growing cells to divide.

引用

页码：251 / 256

页数：6

共 14 条

[1]

DELPORTILLO FG, 1991, FEMS MICROBIOL LETT, V84, P7

[2]

DONACHIE WD, 1993, FEMS S P, V65, P409

[3]

FRAIPONT C, BIOCHEM J, V298, P94

[4]

Garrido T., 1994, NEW COMPR BIOCH, V27, P73, DOI 10.1016/S0167-7306(08)60408-1

[5] ACTIVE-SITE-SERINE D-ALANYL-D-ALANINE-CLEAVING-PEPTIDASE-CATALYZED ACYL-TRANSFER REACTIONS - PROCEDURES FOR STUDYING THE PENICILLIN-BINDING PROTEINS OF BACTERIAL PLASMA-MEMBRANES [J].

GHUYSEN, JM ;

FRERE, JM ;

LEYHBOUILLE, M ;

NGUYENDISTECHE, M ;

COYETTE, J .

BIOCHEMICAL JOURNAL, 1986, 235 (01) :159-165

[6]

GHUYSEN JM, 1994, N COMP BIOC, V27, P103

[7]

GOMEZ MJ, 1993, FEMS S P, V65, P309

[8] GENETIC ANALYSES OF PROCESSING INVOLVING C-TERMINAL CLEAVAGE IN PENICILLIN-BINDING PROTEIN-3 OF ESCHERICHIA-COLI [J].

HARA, H ;

NISHIMURA, Y ;

KATO, JI ;

SUZUKI, H ;

NAGASAWA, H ;

SUZUKI, A ;

HIROTA, Y .

JOURNAL OF BACTERIOLOGY, 1989, 171 (11) :5882-5889

[9] AMINO-ACID SUBSTITUTIONS THAT REDUCE THE AFFINITY OF PENICILLIN-BINDING PROTEIN-3 OF ESCHERICHIA-COLI FOR CEPHALEXIN [J].

HEDGE, PJ ;

SPRATT, BG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 151 (01) :111-121

[10] ON THE PROCESS OF CELLULAR DIVISION IN ESCHERICHIA-COLI - NUCLEOTIDE-SEQUENCE OF THE GENE FOR PENICILLIN-BINDING PROTEIN-3 [J].

NAKAMURA, M ;

MARUYAMA, IN ;

SOMA, M ;

KATO, J ;

SUZUKI, H ;

HOROTA, Y .

MOLECULAR & GENERAL GENETICS, 1983, 191 (01) :1-9

← 1 2 →