DNA TARGETS FOR CERTAIN BZIP PROTEINS DISTINGUISHED BY AN INTRINSIC BEND

被引：75

作者：

PAOLELLA, DN

PALMER, CR

SCHEPARTZ, A

机构：

[1] YALE UNIV,DEPT CHEM,TRAINING PROGRAM BIOPHYS,NEW HAVEN,CT 06511

[2] YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06511

来源：

SCIENCE | 1994年 / 264卷 / 5162期

关键词：

D O I：

10.1126/science.8178171

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In spite of the large amount of sequence conservation among the DNA binding segments of basic region leucine zipper (bZIP) proteins, these proteins can discriminate differently between target sequences that differ in half-site spacing. Here it is shown that the half-site spacing preferences of bZIP proteins are the result of (i) the differential intrinsic curvature in target binding sites that differ by insertion or deletion of a single base pair and (ii) the ability of some bZIP proteins to overcome this intrinsic curvature through a mechanism dependent on basic segment residues.

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页码：1130 / 1133

页数：4

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