FILLER DNA IS ASSOCIATED WITH SPONTANEOUS DELETIONS IN MAIZE

被引:71
作者
WESSLER, S
TARPLEY, A
PURUGGANAN, M
SPELL, M
OKAGAKI, R
机构
[1] Botany Department, University of Georgia, Athens
[2] Genetics Department, University of Wisconsin, Madison
关键词
Mutation; Restriction fragment length polymorphism; Waxy;
D O I
10.1073/pnas.87.22.8731
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have determined the structure of five spontaneous deletions within the maize waxy (Wx) gene. Of these, four were found in spontaneous wx mutants (wx-B, wx-B1, wx-B6, wx-C4) and include exon sequences; the fifth is restricted to an intron and represents a restriction fragment length polymorphism of a nonmutant allele (Wx-W23). The deletions, which range in size from 60 to 980 base pairs (bp), cluster in a G+C-rich region of ≈1000 bp that is capable of forming stable secondary structures. Most striking is our finding that all of the alleles have DNA insertions (filler DNA) of 1-131 bp between the deletion endpoints. For three of the five deletions, the filler DNA and sequences at the deletion termini appear to be derived from sequences near one deletion endpoint. A previously reported spontaneous deletion of the maize bronze gene (bz-R) also contains filler DNA. The association of filler DNA with maize deletion endpoints contrasts dramatically with the rarity of similar events in animal germ-line and bacterial mutations.
引用
收藏
页码:8731 / 8735
页数:5
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