THE EFFECTS OF HALOTHANE ON THE CONTENTS OF PUTATIVE TRANSMITTER AMINO-ACIDS IN WHOLE RAT-BRAIN

被引：6

作者：

ARAI, T ^{[1
]}

AOKI, M ^{[1
]}

MURAKAWA, M ^{[1
]}

NAKAO, S ^{[1
]}

MORI, K ^{[1
]}

KURIHARA, N ^{[1
]}

机构：

[1] KYOTO UNIV,RADIOISOTOPE RES CTR,KYOTO 606,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 117卷 / 03期

关键词：

Amino acid transmitter; Brain content; Gas chromatography-mass spectrometry system; Halothane;

D O I：

10.1016/0304-3940(90)90690-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of halothane on brain amino acid contents were investigated in rat by using a gas chromatography-mass spectrometry system. The contents of glycine and glutamate did not show any consistent changes in 1% or 2% halothane, but increased in 3% or 4% halothane. The levels of γ-aminobutyric acid were not altered in any concentrations of halothane. The levels of aspartate increased in a dose-dependent manner up to 3% halothane, but returned to the control level in 4% halothane. These findings suggest that halothane brings the alteration of brain amino acid contents by affecting their synthesis and catabolism. © 1990.

引用

页码：353 / 357

页数：5

共 11 条

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