POTASSIUM FLUORIDE ON ALUMINA - CONDENSATION OF 1,4-DIACETYLPIPERAZINE-2,5-DIONE WITH ALDEHYDES - DRY CONDENSATION UNDER MICROWAVE IRRADIATION - SYNTHESIS OF ALBONURSIN AND ANALOGS

被引：48

作者：

VILLEMIN, D

BENALLOUM, A

机构：

[1] I.S.M.Ra, U.A.480 CNRS, Université de Caen, F 14050, Caen cedex

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 21期

关键词：

D O I：

10.1080/00397919008051566

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,4-Diacetylpiperazine-2,5-dione (1) was condensated with aldehydes (2) with KF on alumina without solvent under microwaves or in at room temperature in the presence of DMF. The reaction was stereoselective and some natural products (4a-c) like albonursin(4c) were synthesized.

引用

页码：3325 / 3331

页数：7

共 25 条

[1]

ANTEUNIS MJO, 1978, B SOC CHIM BELG, V87, P627

[2]

BENALLOUM A, 1989, J CHEM SOC CHEM COMM, P386

[3] PRODUCTION OF 3-BENZYLIDENE-6-ISOBUTYLIDENE-2,5-DIOXOPIPERAZINE 3,6-DIBENZYLIDENE-2,5-DIOXOPIPERAZINE 3-BENZYL-6-BENZYLIDENE-2,5-DIOXOPIPERAZINE AND 3,6-DIBENZYL-2,5-DIOXOPIPERAZINE BY A VARIANT OF STREPTOMYCES NOURSEI [J].