DISTRIBUTION AND ELIMINATION OF OXOLINIC ACID IN RAINBOW-TROUT (ONCORHYNCHUS-MYKISS WALBAUM) AFTER A SINGLE RAPID INTRAVASCULAR INJECTION

被引：32

作者：

HUSTVEDT, SO

SALTE, R

机构：

[1] AKVAFORSK (Institute of Aquaculture Research), N-1432 Ås -NLH

来源：

AQUACULTURE | 1991年 / 92卷 / 04期

关键词：

D O I：

10.1016/0044-8486(91)90035-6

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Pharmacokinetic studies are important tools in improving the dosage regimens for antibiotics currently in use. In this study elimination half-life, apparent volume of distribution and total clearance of oxolinic acid (OA) were estimated after a single intravascular injection of OA in rainbow trout kept in freshwater and in seawater at 8.5-degrees-C. The drug was given as a rapid injection through a cannula into the dorsal aorta. Repeated blood samples were taken via the cannula and serum was analysed by reversed-phase high-performance liquid chromatography. The terminal elimination half-life for OA in rainbow trout was estimated to be 52.6 h in freshwater (t1/2,beta) and 29.1 h in seawater (t1/2,tau). This considerable difference in elimination half-lives was mainly due to the increase in total clearance; total clearance (Cl(T)) values were 1.2 and 2.0 1 kg-1 24 h-1. The apparent volume of distribution (V(d)(ss)) was estimated to be 2.9 and 2.6 1 kg-1 in freshwater and seawater, respectively.

引用

页码：297 / 303

页数：7

共 17 条

[1]

[Anonymous], 1972, FINNISH FISH RES

[2] CONTROL OF FURUNCULOSIS BY OXOLINIC ACID [J].

AUSTIN, B ;

RAYMENT, J ;

ALDERMAN, DJ .

AQUACULTURE, 1983, 31 (2-4) :101-108

[3]

AUSTIN B, 1987, BACTERIAL FISH PATHO, P331

[4]

BENJAMINSEN T, 1986, THESIS U OSLO

[5] METABOLIC RATES AND CRITICAL SWIMMING SPEEDS OF SOCKEYE SALMON (ONCORHYNCHUS-NERKA) IN RELATION TO SIZE AND TEMPERATURE [J].

BRETT, JR ;

GLASS, NR .

JOURNAL OF THE FISHERIES RESEARCH BOARD OF CANADA, 1973, 30 (03) :379-&

[6]

ENDO T, 1973, B JPN SOC SCI FISH, V39, P165

[7]

ENDO T, 1973, B JPN SOC SCI FISH, V39, P173

[8] PHARMACOKINETICS AND TISSUE DISTRIBUTION OF OXYTETRACYCLINE IN CARP, CYPRINUS-CARPIO L, FOLLOWING DIFFERENT ROUTES OF ADMINISTRATION [J].

GRONDEL, JL ;

NOUWS, JFM ;

DEJONG, M ;

SCHUTTE, AR ;

DRIESSENS, F .

JOURNAL OF FISH DISEASES, 1987, 10 (03) :153-163

[9]

HUNN JB, 1982, PROG FISH CULT, V44, P119, DOI 10.1577/1548-8659(1982)44[119:UFRIFS]2.0.CO

[10]

← 1 2 →