DOES THE PREPUBERTAL DURATION OF DIABETES INFLUENCE THE ONSET OF MICROVASCULAR COMPLICATIONS

被引：53

作者：

MCNALLY, PG ^{[1
]}

RAYMOND, NT ^{[1
]}

SWIFT, PGF ^{[1
]}

HEARNSHAW, JR ^{[1
]}

BURDEN, AC ^{[1
]}

机构：

[1] LEICESTER GEN HOSP,LEICESTER LE5 4PW,ENGLAND

来源：

DIABETIC MEDICINE | 1993年 / 10卷 / 10期

关键词：

PUBERTY; RETINOPATHY; MICROVASCULAR COMPLICATIONS; INSULIN-DEPENDENT DIABETES MELLITUS;

D O I：

10.1111/j.1464-5491.1993.tb00005.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study investigated the relationship between the development of diabetic retinopathy and pubertal status at onset of diabetes in 521 Type 1 diabetic patients diagnosed between 1950 and 1985. Pubertal status was based on age at onset (girls greater than or equal to ll years and boys greater than or equal to 12 years). Retinopathy (all forms) developed in 112 patients (21.5 %; 65 background and 47 proliferative retinopathy). For subjects diagnosed in either the prepubertal or postpubertal period, a similar proportion survived without developing retinopathy for any given duration of diabetes (X(2) = 0.3822, P = 0.54). However, if only the postpubertal duration of diabetes is considered, then the proportion of patients surviving without retinopathy was significantly less for those diagnosed in the prepubertal period (X(2) = 14.2, p = 0.002). This study suggests that the prepubertal duration of diabetes is an important phase and that the years prior to puberty do contribute to the risk of developing microvascular injury.

引用

页码：906 / 908

页数：3

共 16 条

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