TRANS-ACPD INDUCES A SLOW POSTSTIMULUS INWARD TAIL CURRENT (IADP) IN GUINEA-PIG OLFACTORY CORTEX NEURONS INVITRO

被引：15

作者：

CONSTANTI, A ^{[1
]}

LIBRI, V ^{[1
]}

机构：

[1] UNIV ROMA TOR VERGATA 2,DEPT BIOL,I-00173 ROME,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 214卷 / 01期

基金：

英国惠康基金;

关键词：

TRANS-ACPD (TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID); SLOW INWARD TAIL CURRENT (IADP); OLFACTORY CORTEX SLICE (GUINEA-PIG);

D O I：

10.1016/0014-2999(92)90105-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) produced a slow, persistent excitation of guinea-pig olfactory cortical neurones in vitro, and the appearance of a prominent post-stimulus afterdepolarization. The corresponding slow inward tail current (I(ADP)) revealed under voltage clamp was insensitive to tetrodotoxin (or atropine) but was blocked by Cd2+ or tetrabutylammonium. The I(ADP) properties resembled those of the slow inward tail current induced by muscarinic agonists in these neurones. suggesting a common intracellular transduction mechanism.

引用

页码：105 / 106

页数：2

共 5 条

[1] AGONISTS AT METABOTROPIC GLUTAMATE RECEPTORS PRESYNAPTICALLY INHIBIT EPSCS IN NEONATAL RAT HIPPOCAMPUS [J].