ENHANCED MYCN EXPRESSION AND ISOCHROMOSOME 17Q IN PINEALOBLASTOMA CELL-LINES

被引：22

作者：

KEES, UR

BIEGEL, JA

FORD, J

RANFORD, PR

PERONI, SE

HALLAM, LA

PARMITER, AH

WILLOUGHBY, MLN

SPAGNOLO, D

机构：

[1] PRINCESS MARGARET HOSP CHILDREN,DEPT HAEMATOL ONCOL,PERTH,WA,AUSTRALIA

[2] PRINCESS MARGARET HOSP CHILDREN,DEPT ANAT PATHOL,PERTH,WA,AUSTRALIA

[3] CHILDRENS HOSP PHILADELPHIA,DIV HUMAN GENET,PHILADELPHIA,PA 19104

[4] QUEEN ELIZABETH II MED CTR,HOSP PATHOL SERV,PERTH,WA,AUSTRALIA

[5] QUEEN ELIZABETH II MED CTR,UNIV PATHOL SERV,PERTH,WA,AUSTRALIA

来源：

GENES CHROMOSOMES & CANCER | 1994年 / 9卷 / 02期

关键词：

D O I：

10.1002/gcc.2870090209

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have established two cell lines, PER-452 and PER-453, from an 8-month-old girl with an extensive pineoblastoma. Characterization of these lines revealed that the proto-oncogenes MYC and MYCN were not amplified, but both cell lines showed MYCN expression comparable to a cell line with 200-fold MYCN amplification. Both cell lines contained an i(17q). These results support the concept that pineoblastomas belong to a larger group of primitive neuroectodermal tumors of the central nervous system. These two cell lines provide a unique opportunity to investigate the molecular genetic mechanisms underlying these neoplasms further. (C) 1994 Wiley-Liss, Inc.

引用

页码：129 / 135

页数：7

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