TOWARDS A GENERAL FUNCTION DESCRIBING T-CELL PROLIFERATION

被引:124
作者
DEBOER, RJ [1 ]
PERELSON, AS [1 ]
机构
[1] LOS ALAMOS NATL LAB,DIV THEORET,LOS ALAMOS,NM 87545
关键词
D O I
10.1006/jtbi.1995.0165
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A new function is proposed for describing the rate of T cell proliferation in response to peptides on antigen-presenting cells. The model improves an earlier model of ours by allowing for a true maximum proliferation rate of the T cells. This is achieved by a simple change of variables that markedly relaxes the conditions for a conventional quasi-steady-state assumption. The new model has the same ''ecological'' properties as the previous one. Thus the natural competition in the model allows for regulation of T cell population size in the presence of continuous stimulation by antigen. An important feature is the competitive exclusion of T cell clones recognizing the same peptide with different affinities allowing for ''affinity selection''. Models for the population dynamics of experienced, naive and activated T cells are also developed. These T cell subpopulations compete with one another for antigen. In models with lymphokine production a ''proliferation threshold'' is obtained that allows for tolerance. (C) 1995 Academic Press Limited
引用
收藏
页码:567 / 576
页数:10
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