COMPARATIVE COGNITIVE EFFECTS OF PHENOBARBITAL, PHENYTOIN, AND VALPROATE IN HEALTHY-ADULTS

被引:144
作者
MEADOR, KJ
LORING, DW
MOORE, EE
THOMPSON, WO
NICHOLS, ME
OBERZAN, RE
DURKIN, MW
GALLAGHER, BB
KING, DW
机构
[1] MED COLL GEORGIA,DEPT PHARMACOL TOXICOL,AUGUSTA,GA 30912
[2] MED COLL GEORGIA,OFF BIOSTAT,AUGUSTA,GA 30912
关键词
D O I
10.1212/WNL.45.8.1494
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The relative effects of antiepileptic drugs (AEDs) on cognition are controversial. We compared the cognitive effects of phenobarbital, phenytoin, and valproate in 59 healthy adults using a randomized, double-blind, incomplete-block, crossover design. Cognitive assessments were conducted at baseline, after 1 month on each drug (two AEDs per subject), and at two repeat baselines 11 weeks alter each AED treatment. The neuropsychological battery included 12 tests, yielding 22 variables: Choice Reaction Time, P3 Event-Related Potential, Finger Tapping, Lafayette Grooved Pegboard, Selective Reminding Test, Paragraph Memory, Complex Figures, Symbol Digit Modalities Test, Stroop Test, Visual Serial Addition Test; Hopkins Symptom Checklist, and Profile of Mood States. More than one-half of the variables exhibited AED effects when compared with nondrug baselines, and all three AEDs produced some untoward effects. Differential AED effects on cognition were present for approximately one-third of the variables. Phenobarbital produced the worst performance; there was no clinically significant difference between phenytoin and valproate.
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页码:1494 / 1499
页数:6
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