BENZODIPYRAN DERIVATIVES WITH ANTIALLERGIC ACTIVITY

被引:25
作者
BANTICK, JR [1 ]
CAIRNS, H [1 ]
CHAMBERS, A [1 ]
HAZARD, R [1 ]
KING, J [1 ]
LEE, TB [1 ]
MINSHULL, R [1 ]
机构
[1] FISONS LTD, RES & DEV LABS, DIV PHARM, LOUGHBOROUGH, LEICESTERSHIRE, ENGLAND
关键词
D O I
10.1021/jm00228a016
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The synthesis and antiallergic activity of a number of benzodipyrandicarboxylic acids are described. Antiallergic activity of the compounds was determined using the homologous passive cutaneous anaphylaxis (PCA) reaction in the rat. The structural requirements for activity in the PCA screen are discussed. In this test system the linear benzodipyrans are more active than their angular analogs.
引用
收藏
页码:817 / 821
页数:5
相关论文
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