INHIBITION OF HUMAN CYTOMEGALOVIRUS REPLICATION BY 9-(1,3-DIHYDROXY-2-PROPOXYMETHYL)GUANINE ALONE AND IN COMBINATION WITH HUMAN INTERFERONS

被引：39

作者：

RASMUSSEN, L

CHEN, PT

MULLENAX, JG

MERIGAN, TC

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1984年 / 26卷 / 04期

关键词：

D O I：

10.1128/AAC.26.4.441

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The inhibitory action of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on the replication of human cytomegalovirus was studied. Three laboratory strains (AD-169, Towne and Davis) and 3 early passage (< 10) clinical isolates were all inhibited in yield inhibition assays. In cultures infected with AD-169, virus yields could be inhibited if the drug was added as late as 3 days after the replication cycle had begun. The effects of the drug were fully reversible during the first 4 days of the viral replication cycle. Viral infectivity and viral DNA synthesis were reduced more than viral protein synthesis. Synergistic antiviral effects were observed with .beta.-C and to a lesser extent with .beta.-S recombinant interferons, but only over a narrow range of dose combinations.

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页码：441 / 445

页数：5

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