CHRONIC OVERCROWDING DECREASES CYTOPLASMIC FREE CALCIUM LEVELS IN T-LYMPHOCYTES OF AGED CBA/CA MICE

被引：13

作者：

CSERMELY, P ^{[1
]}

PENZES, I ^{[1
]}

TOTH, S ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED,DEPT ANESTHESIOL & INTENS THERAPY,H-1085 BUDAPEST,HUNGARY

来源：

EXPERIENTIA | 1995年 / 51卷 / 9-10期

关键词：

CALCIUM; T LYMPHOCYTES; AGING; PSYCHOSOCIAL STRESS; OVERCROWDING; ANIMAL HOUSING; LYMPHOCYTE ACTIVATION;

D O I：

10.1007/BF01921751

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intracellular calcium concentration is a sensitive marker of the homeostasis of living cells, and its increase is an essential step of T lymphocyte activation. Changes in the environment provoke an adaptive stress-response of the organism. In our present work we have investigated the effect of chronic overcrowding on resting and lectin-stimulated cytoplasmic free calcium concentration of splenic T lymphocytes from young and aged CPA/CA mice (50 animals total). The animals were kept under 'normal' (68 cm(2)/animal) or 'overcrowded' (22 cm(2)/animal) conditions for 3 months. Young animals showed no change in resting and stimulated calcium after overcrowding. T cells from aged mice, however, displayed significantly smaller levels of both resting and lectin-stimulated intracellular calcium concentration (p < 0.01 each), as compared to those of the non-stressed, aged animals. This inadequate adaptation in the calcium metabolism of T lymphocytes may significantly contribute to the diminished immune response of the aged in stress.

引用

页码：976 / 979

页数：4

共 21 条

[1]

BLOOM ET, 1985, STRESS IMMUNITY AGIN, P135

[2]

COHEN JJ, 1984, J IMMUNOL, V132, P38

[3] THE POSSIBLE PITFALLS OF THE MEASUREMENT OF INTRACELLULAR CALCIUM-CONCENTRATION OF LYMPHOCYTES WITH THE FLUORESCENT INDICATOR QUIN2 [J].

CSERMELY, P ;

SOMOGYI, J .

IMMUNOBIOLOGY, 1987, 174 (4-5) :380-394

[4] TUMOR PROMOTER 12-0-TETRADECANOYL-PHORBOL-13-ACETATE (TPA) CAN REDUCE THE CA-TRANSPORTING ABILITY OF CA-IONOPHORES IN LYMPHOCYTES-T - THE INVOLVEMENT OF INTRACELLULAR HEAVY-METAL IONS [J].

CSERMELY, P ;

SOMOGYI, J .

JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (03) :593-602

[5]

CSERMELY P, 1993, RECENT ADVANCES IN AGING SCIENCE, VOLS I AND II, P121

[6]

CSERMELY P, 1995, IN PRESS BIOCH BIOPH

[7]

GHONEUM M, 1987, IMMUNOLOGY, V60, P461

[8]

HESKETH TR, 1983, J BIOL CHEM, V258, P4876

[9]

HOFFMANGOETZ L, 1989, CLIN EXP IMMUNOL, V76, P307

[10] PSYCHOSOCIAL STRESS, DIETARY CALCIUM AND HYPERTENSION IN THE SPONTANEOUSLY HYPERTENSIVE RAT [J].

HUIE, PE ;

HATTON, DC ;

MUNTZEL, MS ;

METZ, JA ;

MCCARRON, DA .

PHYSIOLOGY & BEHAVIOR, 1987, 40 (04) :425-429

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