BINDING OF EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA IN MAMMALIAN PREIMPLANTATION EMBRYOS

被引：9

作者：

FISCHER, B

ROSEHELLEKANT, TA

SHEFFIELD, LG

BERTICS, PJ

BAVISTER, BD

机构：

[1] UNIV WISCONSIN,DEPT ANIM HLTH & BIOMED SCI,MADISON,WI 53706

[2] UNIV WISCONSIN,DEPT DAIRY SCI,MADISON,WI 53706

[3] UNIV WISCONSIN,DEPT BIOMOLEC CHEM,MADISON,WI 53706

来源：

THERIOGENOLOGY | 1994年 / 41卷 / 04期

关键词：

EPIDERMAL GROWTH FACTOR (EGF); TRANSFORMING GROWTH FACTOR-ALPHA (TGF-ALPHA); PREIMPLANTATION EMBRYOS; PIG; COW;

D O I：

10.1016/0093-691X(94)90503-B

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Preimplantation embryos of the pig (Days 11 to 15), cow (Days 14 to 16), sheep (Day 14) and pony (Day 16) bind epidermal growth factor (EGF) specifically Binding was not detected in embryos of the rabbit at Day 5 or 6 or the hamster at Day 3. Transforming growth factor-alpha displaced [I-125] EGF in pig, cow and pony embryos almost as much as unlabeled EGF. The binding affinities of EGF ranged from 12 to 233 pM in pig and cow embryos. The range of species and binding features indicate that the EGF family may play a significant role in mammalian preimplantation development.

引用

页码：879 / 887

页数：9

共 36 条

[1]

GROWTH, PROTEIN-CONTENT AND DISTRIBUTION OF EARLY PIG EMBRYOS [J].