IMMUNOSUPPRESSIVE ACTIVITY IN HUMAN EMBRYO GROWTH MEDIA IS ASSOCIATED WITH SUCCESSFUL PREGNANCY - EFFECT OF GONADOTROPIN-RELEASING HORMONE AGONIST (GNRHA) TREATMENT OF PATIENTS UNDERGOING INVITRO FERTILIZATION AND EMBRYO TRANSFER (IVF-ET)

被引：14

作者：

BOSE, R ^{[1
]}

MAHADEVAN, MM ^{[1
]}

机构：

[1] ARIZONA FERTIL INST, PHOENIX, AZ 85008 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1990年 / 10卷 / 03期

关键词：

embryo; gonadotropin releasing hormone agonist (GnRHa); Immunosuppression; in vitro fertilization and embryo transfer (IVF-ET); pregnancy;

D O I：

10.1007/BF00917918

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of the present study was to determine whether the secretion of embryo-associated immunosuppressor factor (EASF) by preimplantation embryo correlates with pregnancy outcome and whether this relationship is influenced by pretreatment of gonadotropin releasing hormone agonist (GnRHa) in patients undergoing in vitro fertilization and embryo transfer (IVF-ET). EASF activity was measured using concanavalin A-induced human lymphocyte proliferation assay in 256 embryo growth media obtained from 61 patients undergoing IVF-ET. EASF activity was then correlated with GnRHa treatment and pregnancy outcome in these IVF patients. Results indicate that (i) the presence of immunosuppressive activity in human embryo growth media is associated with success of pregnancy in GnRHa nontreated patients and (ii) serum factors present in GnRHa-treated patients may affect the EASF secretion by preembryos in vitro. © 1990 Plenum Publishing Corporation.

引用

页码：175 / 181

页数：7

共 19 条

[1] LACK OF CORRELATION OF IMMUNOSUPPRESSIVE ACTIVITY SECRETED BY HUMAN INVITRO FERTILIZED (IVF) OVA WITH SUCCESSFUL PREGNANCY [J].

ARMSTRONG, DT ;

CHAOUAT, G ;

GUICHARD, A ;

CEDARD, L ;

ANDREU, G ;

DENVER, L .

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER, 1989, 6 (01) :15-21

[2] PURIFIED HUMAN EARLY-PREGNANCY FACTOR FROM PREIMPLANTATION EMBRYO POSSESSES IMMUNOSUPPRESSIVE PROPERTIES [J].

BOSE, R ;

CHENG, H ;

SABBADINI, E ;

MCCOSHEN, J ;

MAHADEVAN, MM ;

FLEETHAM, J .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 160 (04) :954-960

[3] HUMAN-EMBRYO ASSOCIATED IMMUNOSUPPRESSOR FACTOR(S) FROM PRE-IMPLANTATION AND POST-IMPLANTATION STAGES SHARE SOME SIMILARITIES [J].

BOSE, R .

IMMUNOLOGY LETTERS, 1989, 20 (04) :261-267

[4]

BOSE R, IN PRESS AM J OBSTET

[5] THE IMPACT OF EMBRYO QUALITY AND QUANTITY ON IMPLANTATION AND THE ESTABLISHMENT OF VIABLE PREGNANCIES [J].

CLAMAN, P ;

ARMANT, DR ;

SEIBEL, MM ;

WANG, TA ;

OSKOWITZ, SP ;

TAYMOR, ML .

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER, 1987, 4 (04) :218-222

[6] IMMUNOSUPPRESSIVE ACTIVITY IN HUMAN INVITRO FERTILIZATION (IVF) CULTURE SUPERNATANTS AND PREDICTION OF THE OUTCOME OF EMBRYO TRANSFER - A MULTICENTER TRIAL [J].

CLARK, DA ;

LEE, S ;

FISHELL, S ;

MAHADEVAN, M ;

GOODALL, H ;

MOYE, MA ;

SCHECHTER, O ;

STEDRONSKACLARK, J ;

DAYA, S ;

UNDERWOOD, J ;

CRAFT, I ;

MOWBRAY, J .

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER, 1989, 6 (01) :51-58

[7]

DAYA S, 1988, FERTIL STERIL, V49, P360

[8]

DAYA S, 1986, AM J REPROD IMMUNOL, V11, P98

[9]

Daya Salim, 1986, REPRODUCTIVE IMMUNOL, P277

[10] IMPROVEMENTS IN OVARIAN STIMULATION FOR INVITRO FERTILIZATION [J].

FRYDMAN, R ;

FORMAN, RG ;

BELAISCHALLART, J ;

HAZOUT, A ;

RAINHORN, JD ;

FRIES, N ;

TESTART, J .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1988, 541 :30-36

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