SYNTHESIS OF SIALIC-ACID PSEUDOPOLYSACCHARIDES BY COUPLING OF SPACER-CONNECTED NEU5AC WITH ACTIVATED POLYMER

被引：49

作者：

BYRAMOVA, NE ^{[1
]}

MOCHALOVA, LV ^{[1
]}

BELYANCHIKOV, IM ^{[1
]}

MATROSOVICH, MN ^{[1
]}

BOVIN, NV ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI,INST POLIOMYELITIS & VIRAL ENCEPHALITIDES,MOSCOW 142782,RUSSIA

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1080/07328309108543942

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new approach to the synthesis of polyvalent sialosides (pseudopolysaccharides) of Neu5Ac is described. Two monovalent sialosides, namely 4-acetamido- and 4-glycylamidobenzyl alpha-glycosides of Neu5Ac (and their beta-anomers) have been synthesized. The latter, each having a free amino group, have been coupled with poly(4-nitrophenylacrylate) followed by treatment with sodium hydroxide or ethanolamine to give water soluble polyvalent sialosides differing in the nature of polymeric backbone. The coupling proceeded quantitatively providing polymers with a desired number of spacer-connected Neu5Ac residues attached. The polymers are shown to have considerable activity as inhibitors of influenza virus adhesion.

引用

页码：691 / 700

页数：10

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