EFFECTS OF VARIOUS TACHYKININS ON PITUITARY LH-SECRETION, FEEDING, AND SEXUAL-BEHAVIOR IN THE RAT

被引：24

作者：

KALRA, SP

SAHU, A

DUBE, MG

KALRA, PS

机构：

[1] Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 1991年 / 632卷

关键词：

D O I：

10.1111/j.1749-6632.1991.tb33120.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Our investigations of the four tachykinins tested have shown that NPK characteristically evoked a spectrum of biological effects in male and female rats. NPK suppressed pituitary LH release by inhibiting the release of hypothalamic LHRH, presumably by activation of NK‐2 tachykinin receptor subtypes. However, NPK may also act at the level of gonadotrophs to stimulate LH release in male rats. Central injection of NPK rapidly disrupted copulatory behavior in sexually active male rats. NPK also suppressed feeding, but, in this case, peripheral injections were more effective than central injections. Taken together, these observations strongly imply that NPK may be an inhibitory messenger molecule in the hypothalamic control of reproduction, sexual, and feeding behaviors. Copyright © 1991, Wiley Blackwell. All rights reserved

引用

页码：332 / 338

页数：7

共 30 条

[1] STIMULATORY ROLE OF SUBSTANCE-P ON GONADOTROPIN-RELEASE IN OVARIECTOMIZED RATS [J].