EICOSANOID PRODUCTION BY THE MUCOSA IN INFLAMMATORY BOWEL-DISEASE AFTER 5-ASA TREATMENT

被引:10
作者
ZIJLSTRA, FJ
VANDIJK, APM
OUWENDIJK, RJT
VANRIEMSDIJKOVERBEEKE, IC
WILSON, JHP
机构
[1] UNIV HOSP DIJKZIGT,DEPT INTERNAL MED 2,ROTTERDAM,NETHERLANDS
[2] IKAZIA HOSP,DEPT INTERNAL MED,ROTTERDAM,NETHERLANDS
来源
AGENTS AND ACTIONS | 1993年 / 38卷
关键词
ULCERATIVE-COLITIS; SULFASALAZINE; INHIBITION; PROSTAGLANDINS;
D O I
10.1007/BF01991158
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of C-14-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxy-eicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score.
引用
收藏
页码:C122 / C124
页数:3
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