SYNTHESIS AND PROPERTIES OF 6A-AMINO-6A-DEOXY-ALPHA AND 6A-AMINO-6A-DEOXY-BETA-CYCLODEXTRIN

被引：64

作者：

BROWN, SE ^{[1
]}

COATES, JH ^{[1
]}

COGHLAN, DR ^{[1
]}

EASTON, CJ ^{[1
]}

VANEYK, SJ ^{[1
]}

JANOWSKI, W ^{[1
]}

LEPORE, A ^{[1
]}

LINCOLN, SF ^{[1
]}

LUO, Y ^{[1
]}

MAY, BL ^{[1
]}

SCHIESSER, DS ^{[1
]}

WANG, P ^{[1
]}

WILLIAMS, ML ^{[1
]}

机构：

[1] UNIV ADELAIDE, DEPT CHEM, GPO BOX 498, ADELAIDE, SA 5001, AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1993年 / 46卷 / 06期

关键词：

D O I：

10.1071/CH9930953

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The monotosylates obtained by treatment of alpha- and beta-cyclodextrin with p-methylbenzenesulfonyl chloride reacted with ammonia to give the title compounds. These amines are of unusually low basicity, with pK(a) values of 8.70 and 8.72, respectively. In water at 25-degrees, the hydrochloride salt of the amine derived from beta-cyclodextrin is approximately 40 times more soluble than beta-cyclodextrin and, through complexation, the salt increases the solubility of Nabumetone over 800 times.

引用

页码：953 / 958

页数：6

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