SYNTHETIC STUDY OF CURACIN-A - SYNTHESIS OF PARTIAL STRUCTURE OF CURACIN-A AND ELUCIDATION OF THE ABSOLUTE STEREOCHEMISTRY AT THE METHYLCYCLOPROPYLTHIAZOLINE MOIETY

被引：19

作者：

ONODA, T ^{[1
]}

SHIRAI, R ^{[1
]}

KOISO, Y ^{[1
]}

IWASAKI, S ^{[1
]}

机构：

[1] UNIV TOKYO, INST MOLEC & CELLULAR BIOSCI, BUNKYO KU, TOKYO 113, JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 32期

关键词：

D O I：

10.1016/0040-4039(95)01134-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We defined the absolute configurations of three chiral centers in curacin A (1), a novel antimitotic agent isolated from a marine cyanobacterium, as 2R, 19R and 21S, by synthesizing the four stereoisomers of a partial structure of 1, 2-(2-methyl)cyclopropyl-4-(1-propenyl)thiazoline, (+)- and (-)- 2a, 2b.

引用

页码：5765 / 5768

页数：4

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